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Low-Extraction Drugs (Low E): These drugs are not significantly metabolized on the first pass and therefore tend to have a high oral bioavailability (F is high)

In September 2023, FDA placed "Thymosin Beta-4, Fragment (LKKTETQ)," the substance sold as TB-500, on Category 2 of its interim 503A bulk drug substances list, meaning FDA identified significant safety concerns and would not permit licensed compounding pharmacies to use it

Unlike pharmaceuticals, many peptides mimic endogenous compounds the human body naturally produces, allowing for physiologic-level optimization with a favorable safety profile (Rossi et al., 2022)

Administered as an injectable or oral forms